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The myometrium, a thick muscular layer of the uterine tissue, plays an important role in various reproductive functions along with a key role in labour. There has been remarkable progress towards understanding the physiology and clinical pathophysiology of the myometrium, however, the molecular mechanisms and genetic basis underlying its activity are very poorly understood. Gene regulation is a result of the complex interplay between transcriptional factors and regulatory regions within our DNA which allow the myometrium to transition into various phenotypes. My research project focuses on the role of these myometrium transcriptional factors and their regulation processes during the various stages of pregnancy and labour. For this, I aim to carry out experiments involving next generation sequencing techniques on myometrium tissue and conduct downstream genetic analysis.